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phenobarbital will increase toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. CYP3A4 inducers may possibly enhance the metabolism of ifosfamide to its Energetic alkylating metabolites.Hypnotic doses of barbiturates will not appear to impair uterine action considerably in the course of lab

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